Serdar E Bulun Selected Research

Progesterone

1/2022	Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.
1/2021	Progesterone receptor-DNA methylation crosstalk regulates depletion of uterine leiomyoma stem cells: A potential therapeutic target.
11/2020	Menstruation: science and society.
1/2019	Progesterone receptor integrates the effects of mutated MED12 and altered DNA methylation to stimulate RANKL expression and stem cell proliferation in uterine leiomyoma.
9/2015	Uterine Leiomyoma Stem Cells: Linking Progesterone to Growth.
8/2015	Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution.
5/2015	Molecular biology of endometriosis: from aromatase to genomic abnormalities.
1/2015	Ovarian steroids, stem cells and uterine leiomyoma: therapeutic implications.
10/2013	Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth.
2/2013	Progesterone action in endometrial cancer, endometriosis, uterine fibroids, and breast cancer.

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Serdar E Bulun Research Topics

Disease

49	Endometriosis 12/2021 - 03/2002
39	Leiomyoma (Uterine Fibroids) 01/2022 - 09/2005
36	Neoplasms (Cancer) 05/2021 - 07/2002
23	Breast Neoplasms (Breast Cancer) 01/2017 - 10/2002
9	Pelvic Pain 01/2019 - 07/2002
8	Inflammation (Inflammations) 01/2019 - 03/2006
8	Pain (Aches) 05/2015 - 02/2004
7	Endometrial Neoplasms (Endometrial Cancer) 01/2016 - 09/2005
6	Uterine Hemorrhage (Uterine Bleeding) 11/2020 - 05/2007
5	Infertility (Sterility) 01/2019 - 07/2002
4	Carcinogenesis 01/2022 - 10/2013
2	Hernia (Hernias) 01/2022 - 10/2018
2	Inguinal Hernia (Direct Inguinal Hernia) 01/2022 - 10/2018
2	Fibrosis (Cirrhosis) 01/2022 - 10/2018
2	Weight Gain 01/2022 - 05/2012
2	Adenomyosis 10/2021 - 11/2020
2	Choristoma (Ectopic Tissue) 02/2013 - 07/2002
2	Hyperplasia 06/2012 - 02/2012
2	Choriocarcinoma 07/2009 - 10/2003
2	Ovarian Neoplasms (Ovarian Cancer) 01/2008 - 08/2007
2	Gynecomastia 11/2007 - 05/2003
2	Uterine Diseases (Endometrial Disease) 09/2005 - 05/2005
1	Overweight 01/2022
1	Smooth Muscle Tumor 05/2021
1	Glioma (Gliomas) 01/2019
1	Endometrial Stromal Sarcoma 01/2019
1	Ovarian Epithelial Carcinoma 01/2019
1	Atrophy 10/2018

Drug/Important Bio-Agent (IBA)

53	Estrogens (Estrogen)FDA Link 01/2022 - 03/2002
41	Aromatase (CYP19)IBA 01/2022 - 03/2002
25	Aromatase InhibitorsIBA 10/2018 - 03/2002
22	Progesterone FDA LinkGeneric 01/2022 - 05/2003
19	Messenger RNA (mRNA)IBA 01/2022 - 09/2003
19	Progesterone Receptors (Progesterone Receptor)IBA 01/2021 - 09/2004
15	Estradiol (Delestrogen)FDA LinkGeneric 10/2018 - 03/2002
12	EnzymesIBA 01/2022 - 07/2002
11	Estrogen ReceptorsIBA 01/2022 - 02/2009
9	Hormones (Hormone)IBA 01/2022 - 02/2004
9	Proteins (Proteins, Gene)FDA Link 01/2019 - 02/2004
8	SteroidsIBA 10/2021 - 03/2006
7	Biological ProductsIBA 01/2019 - 03/2006
7	Transcription Factors (Transcription Factor)IBA 05/2015 - 09/2003
6	ProstaglandinsIBA 05/2015 - 02/2004
5	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 01/2019 - 01/2009
5	RetinoidsIBA 01/2019 - 11/2010
4	ChromatinIBA 01/2022 - 05/2007
4	Estrogen Receptor alphaIBA 01/2019 - 05/2007
4	LigandsIBA 01/2018 - 05/2007
4	Estrogen Receptor betaIBA 01/2018 - 10/2007
4	Progestins (Progestagens)IBA 01/2014 - 03/2006
4	Estrone FDA Link 08/2011 - 03/2002
4	Dinoprostone (PGE2)FDA Link 05/2011 - 03/2002
4	Prostaglandins EIBA 05/2011 - 05/2002
3	Mediator ComplexIBA 01/2022 - 01/2012
3	RNA (Ribonucleic Acid)IBA 01/2022 - 05/2021
3	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 11/2014
3	CateninsIBA 12/2020 - 10/2013
3	Pharmaceutical PreparationsIBA 10/2020 - 09/2007
3	Steroid Receptors (Steroid Receptor)IBA 09/2015 - 09/2003
3	Mifepristone (RU 486)FDA Link 01/2012 - 11/2009
3	Letrozole (Femara)FDA LinkGeneric 10/2011 - 07/2002
3	MitogensIBA 01/2010 - 05/2003
2	PromegestoneIBA 01/2022 - 11/2007
2	lipoarabinomannan (LAM)IBA 01/2022 - 10/2018
2	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 01/2022 - 10/2015
2	Histones (Histone)IBA 01/2022 - 01/2019
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2009
2	AndrogensIBA 10/2018 - 01/2015
2	CytokinesIBA 01/2018 - 01/2009
2	GlycodelinIBA 01/2018 - 09/2003
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017 - 02/2010
2	FenretinideIBA 01/2016 - 01/2014
2	CollagenIBA 01/2016 - 02/2010
2	MicroRNAs (MicroRNA)IBA 01/2016 - 06/2008
2	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 11/2014 - 02/2006
2	Antineoplastic Agents (Antineoplastics)IBA 05/2014 - 01/2014
2	Protein Isoforms (Isoforms)IBA 03/2014 - 03/2006
2	Tamoxifen FDA LinkGeneric 01/2013 - 07/2009
2	Small Interfering RNA (siRNA)IBA 02/2010 - 01/2009
2	Phosphotransferases (Kinase)IBA 02/2010 - 09/2007
2	due to increased aromatase activity familial gynecomastiaIBA 11/2007 - 09/2005
1	phthalic acid (phthalate)IBA 01/2022
1	Tryptophan Oxygenase (Tryptophan 2,3 Dioxygenase)IBA 01/2022
1	Tryptophan (L-Tryptophan)FDA Link 01/2022
1	KynurenineIBA 01/2022
1	Butyrates (Butyrate)IBA 12/2021
1	Volatile Fatty AcidsIBA 12/2021
1	Fumarate Hydratase (Fumarase)IBA 05/2021
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 12/2020
1	COUP Transcription Factor IIIBA 01/2019
1	Polycomb Repressive Complex 2IBA 01/2019
1	Methionine (L-Methionine)FDA Link 01/2019
1	Cyclooxygenase InhibitorsIBA 01/2019
1	AcetyltransferasesIBA 01/2019
1	Testosterone (Sustanon)FDA Link 10/2018

Therapy/Procedure

21	Therapeutics 01/2021 - 08/2005
8	Hysterectomy 12/2020 - 06/2008
3	Aftercare (After-Treatment) 01/2021 - 10/2011
2	Uterine Myomectomy 12/2020 - 05/2014
1	Ovulation Inhibition 01/2019